About Odyssey House
Odyssey House is a substance use treatment program in New York City, New York, offering a full continuum of care for adults, adolescents and families affected by addiction and cooccurring mental health disorders.
Located at 219 East 121st Street in East Harlem, the program provides residential treatment, outpatient services, an opioid treatment program and reentry supports.
Odyssey House uses an integrated, whole person approach that addresses substance use, mental health and needs related to housing, employment and health care.
The Opioid Treatment Program
Care may begin with an assessment to determine the right level of support, from structured residential services to flexible outpatient treatment that allows clients to maintain work, school and family responsibilities.
The Opioid Treatment Program (OTP) offers medications for opioid use disorder, including methadone, buprenorphine and naltrexone, paired with counseling.
Clients can expect counseling, case management and integrated care for cooccurring disorders.
Odyssey House also provides reentry services for individuals returning from incarceration and specialized supports for families, young people, and those experiencing homelessness.
Quick Facts About Odyssey House
- Location: East Harlem, Manhattan, in an urban, community based setting
- Levels of care: Residential treatment, outpatient services and an opioid treatment program
- Who they treat: Adults, adolescents and families, including cooccurring mental health disorders
- Approach: Integrated, whole person care with medical and recovery support services
- Specialty programs: Reentry services, school based supports and services for people experiencing homelessness
- Medication support: Methadone, buprenorphine and naltrexone available through the OTP
Getting Started
To begin treatment at Odyssey House in New York City, prospective clients can complete an assessment and intake to identify the most appropriate level of care.
The admissions team can explain available programs and review payment and eligibility options.




