5 Long-Term Effects of Painkillers on the Brain

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Painkillers, or opioids, are commonly prescribed for short-term use to treat moderate to severe pain such as that caused by injury and surgery. Painkillers have been used to treat pain since the early 20th century, but became more widely used during the 1990s when oxycodone was released under the brand name OxyContin. Today, more than one in every three Americans, or roughly 38 percent of the United States population, takes a legitimately prescribed painkiller for valid medical reasons.

While opioids may be touted as one of the most effective pain treatments available in the U.S., these substances are highly addictive, and can cause a range of adverse long-time effects on the brain. Using painkillers for over 30 days or for an extended period of time can increase one’s risk for dependence, addiction, and other long-term health problems. Long-term use of painkillers can cause the brain and body to adapt to these drugs over time, and alter normal bodily functions that are vital to maintaining good overall health.

Are you or a loved one currently using prescription painkillers? Here’s how painkillers affect the brain, and what you can do to prevent you and your loved ones from becoming addicted to these potent, dangerous substances that carry a high risk for abuse and dependence.

Long term effects of painkillers on the brain

Painkiller Addiction Rates Are On the Rise

In recent years, painkiller abuse and addiction has become a serious national crisis in the U.S. Roughly 1.9 million Americans, or 0.8 percent of the U.S. population suffer from opioid dependence and addiction. More than 63 percent of those who misuse painkillers report doing so to relieve physical pain. Additionally, 41 percent of those who misuse painkillers admit to having obtained painkillers illicitly and for free from friends and relatives.

The overprescribing of opioids by doctors continues to fuel the U.S. opioid epidemic. In states like Mississippi and Alabama, there are enough painkiller prescriptions written to put opioids in the hands of nearly every state resident. Many doctors even prescribe a higher number of painkillers to patients than necessary — resulting in bottles of extra, unused painkillers being stored in medicine cabinets across the U.S.

Long term effects of painkillers on the brain

Today, almost half of all opioid overdose deaths in the U.S. involve a prescription painkiller. In 2015, more than 15,000 people died from overdoses involving prescription opioids including oxycodone, hydrocodone, and fentanyl. The painkiller epidemic is even contributing to a lower life expectancy for U.S. men and women.

Despite these haunting statistics, painkiller addiction in the U.S. continues to be on the rise. Painkiller addiction is even leading to an increase in heroin use, since heroin is often more potent, lower in cost, and easier to obtain than painkillers. Heroin-related overdose deaths increased by 286 percent from 2002 to 2015 on behalf of the rising painkiller epidemic.

5 Long-Term Effects of Painkillers on the Brain

Regular, repeated use of painkillers can have multiple long-term effects on the brain. Over time, the brain adapts to the presence of painkillers and stops functioning normally on its own. This effect can start a chain reaction of serious long-term health problems that often require intensive care and rehabilitation.

A recent study found that using painkillers for as little as 30 days can reduce the volume of brain matter responsible for regulating emotions, cravings, and pain. Using painkillers for an extended period of time can exacerbate this type of brain loss, and lead to a range of other health problems.

Here are five long-term effects of painkillers on the brain.

1. Depression

Long-term use of painkillers increases the risk for depression. A recent study found that those who use painkillers for a minimum of 180 days are 53 percent more likely to suffer depression than those who use painkillers for a shorter period of time.

Depression is commonly treated using psychotherapy and medications, and can take months or years to overcome. Many times, depression can increase the risk for addiction, and vice versa. The presence of addiction and mental health disorders at the same time is known as a dual diagnosis or co-occurring disorders, which can be effectively treated using medications and psychotherapy at most addiction treatment centers.

2. Disruption in Neurotransmitters

Painkillers work to reduce pain by binding to opioid receptors in the brain responsible for controlling our feelings of reward and pleasure. Painkillers alter the way the brain perceives pain, and allows users to feel euphoric, relaxed, and sedated.

With long-term painkiller use, the brain adapts to the presence of painkillers and stops producing its own hormones and chemicals responsible for controlling pain and pleasure. Eventually, the brain comes to rely on painkillers to produce these chemicals — also known as neurotransmitters. When people suddenly stop taking painkillers, their brains are unable to produce neurotransmitters in the amounts needed to manage feelings of pain, reward, and pleasure on their own.

A person’s brain can resume normal production of these neurotransmitters after quitting painkillers and going through professional drug detox. However, this healing process can take months or years after someone overcomes painkiller dependency.

3. Impaired Cognition

Long-term use of painkillers has been shown to destroy brain cells associated with learning, memory, and cognition. A recent study found that long-term use of opioids can reduce blood flow to the brain over a period of time, and trigger short-term memory loss. Another study found that heavy or long-term opioid use increases one’s risk for dementia and cognitive decline.

Long term effects of painkillers on the brain

Symptoms associated with dementia and poor cognition are commonly treated using medications that help enhance memory, as well as talk therapy, rehabilitation, and occupational therapy. Some addiction treatment centers offer specialized therapies that can help patients manage cognition problems while overcoming painkiller addiction at the same time.

4. Physical Dependency

A person who uses painkillers regularly can eventually become tolerant to their medication, and require higher amounts just to feel its effects. Those who become tolerant to painkillers usually increase their doses, or take the drug more frequently. When this happens, increased tolerance can quickly turn into physical dependence.

Those who become physically dependent on painkillers will require certain doses of the drug to avoid drug cravings and other withdrawal symptoms. With physical dependence, the brain has adapted to the presence of painkillers, and relies on these substances to experience feelings of pleasure, reward, and pain relief. A person dependent on painkillers will experience unpleasant withdrawal symptoms that range from moderate to severe when quitting or reducing use, such as vomiting, sweating, diarrhea, and more.

5. Addiction

Using painkillers for more than seven days can significantly increase one’s risk for addiction. A person who becomes physically dependent on painkillers will fall into a habitual pattern of using the drug regularly, and may rely on the drug to relax and wind down. Addiction is defined a chronic relapsing brain disease, and can cause a number of emotional and behavioral changes due to the way substances like painkillers alter brain function.

Addiction can severely impact one’s physical and psychological health, and lead to serious problems with finances, career, family, and law enforcement. Painkiller addiction can be fully and effectively battled at addiction treatment centers that offer detox, counseling, and continuing care programs.

Common Misconceptions About Painkillers

Painkiller addiction is often unintentional, and happens when people misuse their medications. Many Americans tend to think that painkillers are completely safe since these medications are commonly prescribed by their doctors, and often lack general knowledge about how painkillers affect the body and brain. Misconceptions about painkillers are a leading driver behind the U.S. opioid epidemic and unintentional painkiller overdose deaths.

Here are common misconceptions about painkillers:

Long term effects of painkillers on the brain

Myth #1: Painkillers Can Fix Pain

Many believe they need to use painkillers long-term or indefinitely to fix health problems that cause pain. But painkillers only block and mask feelings of pain, and do not treat root causes of pain.

Myth #2: Higher Doses of Painkillers are More Effective

Some painkiller users will double up on doses or take them more frequently as directed under the impression that a higher amount is better for pain management. But taking higher doses increases one’s risk for an overdose, as well as tolerance and physical dependence.

Myth #3: Painkillers Aren’t Addictive

Some painkiller users who take the drugs for legitimate medical reasons think that addiction can’t happen to them since they have a valid prescription. But addiction can affect anybody, regardless of family background, environment, socioeconomic status, and other factors.

The Highly Addictive Nature of Painkillers

Before you or your loved one decides to treat short-term pain using painkillers, take time to learn about the effects of painkillers, and how even short-term use can lead to dependence and addiction. Painkiller use not only causes changes to the brain, but has been linked to a number of other long-term side effects. Even those who use painkillers for just a short period of time are at risk for developing serious health problems.

Common long-term health effects of painkiller use:

  • Lowered immunity. Painkiller use compromises the immune system, and can make one more vulnerable to illness and disease.
  • Respiratory failure. Painkillers slow down respiratory function, and can cause long-term problems with breathing and collapse of the respiratory system.
  • Heart problems. Painkillers slow heart rate, cause irregular heartbeat, and increase the risk for heart disease.
  • Liver and kidney problems. Painkiller use puts undue strain on the liver, and can lead to liver disease or liver failure. Painkiller use can also lead to the breakdown of muscle and tissue, which increases the risk for kidney disease and kidney failure.
  • Gastrointestinal problems. Painkiller use can cause constipation and other gastrointestinal problems such as bloating, nausea, and vomiting.
  • Death. Misusing painkillers can lead to unintentional toxicity, overdose, and death.

Understanding the risks associated with painkiller use can help you and your loved ones make the best informed decisions when it comes to healthcare. Addiction to painkillers can be avoided as long as you educate yourself and your family members on the potential risks, and on how to use painkillers safely and properly as prescribed.

How to Avoid Addiction to Painkillers

Anyone who uses painkillers is at risk for addiction — including yourself and others you may not think are susceptible to addiction.

Here are tips on how to avoid addiction to painkillers so you and your loved ones can stay as safe and healthy as possible.

Long term effects of painkillers on the brain

  • Know your risk factors. Genetics, environment, and mental health disorders like depression are common risk factors for painkiller addiction. Familiarize yourself with the risk factors of painkiller addiction before deciding to treat pain using opioids.
  • Take your medication as prescribed. Read the labels and directions on your painkillers, and take the proper dosage only when specified. Misusing your painkiller medication greatly increases the risk for addiction.
  • Consider alternative pain treatments. Ask your doctor about other pain relief methods that carry a far lower risk for addiction, such as acupuncture, yoga, and meditation.
  • Limit painkiller use to no more than seven days. Taking painkillers for a maximum of seven days can effectively treat your pain with a lowered risk for addiction, since evidence shows using painkillers for 30 days or longer can lead to dependence.
  • Don’t use painkillers given to you by friends and family. Painkillers vary in potency levels and doses, and can be short-acting or long-acting. Never use painkillers that have been prescribed to someone else, since the effects and potency levels of some opioids can lead to an overdose after initial use in some individuals.